Cell
Feb 29, 2024 Volume 187 Issue 5 p1017-1314
Leading Edge
Five decades of genetics and genomics
The Cell Editorial Team
Some of the most significant discoveries in the life sciences over the last 50 years stem from genetics and genomics. This field has also seen large-scale collaborative efforts yield fundamental milestones and results, such as the Human Genome Project. Despite a long road ahead, progress in both basic and clinical genetics now drives sweeping efforts to cure complex human ailments such as blood and psychiatric disorders, metabolic diseases, cancer, and neurodegeneration. While these large tent-pole endeavors receive the most attention, cutting-edge modern genetics techniques are foundational to the science that happens daily across the biomedical life sciences.

Past, present, and future of CRISPR genome editing technologies
Martin Pacesa, Oana Pelea, Martin Jinek
A broad survey of the genome editing landscape, highlighting the potential and the challenges of genome editing applications for research and therapeutics.